TH9-Derived IL-9 has been shown to exacerbate the allergic immune response by enhancing antibody production and increasing cell infiltration inside of the respiratory tract. Targeting EC–tumor cell interaction may be beneficial in developing anti‐metastasis approaches. /ColorSpace/DeviceCMYK C.F. Despite the bias in this study, such as the small sample size and the inclusion of tumours up to 3cm in size, the western world grew sceptical towards sublobar resections, and lobectomy became the treatment of choice for lung cancer. The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis. Recently, the clinical onset of combined therapy protocols, the recognised value of the intrathoracic sta... Will Rogers phenomenon affects survival statistics applied to clinical research and could determine a misreading of results. Penso a quegli attimi,ai mille pensieri che affollavano la [10], IL-25 also induces IL-9 production in vivo.[11]. It was also observed that the epigenetic modification that occurred in the tumor microenvironment was also involved in the increased expression of biglycan in TEC.39. [3][4] while TGF-β alone can switch TH2 cells into TH9 cells. Instead, N2 is considered to be the worst prognostic factor for intrathoracic extended disease. If you do not receive an email within 10 minutes, your email address may not be registered, Effect of magnesium-degradation products and hypoxia on the angiogenesis of human umbilical vein endothelial cells. Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p. Dynamic adhesion characterization of cancer cells under blood flow-mimetic conditions: effects of cell shape and orientation on drag force. Perineurioma of the colon: an uncommon tumor with an unusual location. [22][11][6][23][24][25][26][27], The main physiological role of TH9 cells, while poorly defined, is defense against helminthic infections. /Type/XObject Recently, researchers have studied the role of stromal cells in the tumor microenvironment. These cells adapt to the new microenvironment and proliferate for metastatic colonization2 (Fig. Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. Tumor cell transendothelial migration was enhanced on the HM‐TEC monolayer. Surgical technique and long-term results], Bronchoplasty versus carinoplasty: the oncological value of two methods. Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors. Reprinted from Maishi, By continuing to browse this site, you agree to its use of cookies as described in our,, I have read and accept the Wiley Online Library Terms and Conditions of Use, The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Tumor‐associated endothelial cells with cytogenetic abnormalities, Heterogeneity of tumor endothelial cells and drug delivery, Microenvironmental regulation of tumor progression and metastasis, The biology and function of fibroblasts in cancer, Tumors: wounds that do not heal. Pore‐Scale Modeling of Fluid‐Fluid Interfacial Area in Variably Saturated Porous Media Containing Microscale Surface Roughness. Via Ernesto Lugaro n. 15 - 00126 Torino - P.I. /Length 107450 Temperature‐Directed Micellar Morphological Transformation Using CABC‐Block Copolymers and Its Applications in Encapsulation and Hidden Segment. Tumor endothelial cells, which line tumor blood vessels, also exhibit several altered phenotypes compared with those of their normal counterparts. The role of protein disulphide isomerase AGR2 in the tumour niche. Does endobronchial lesion affect the lymph node status in non-small cell lung cancer? X���yl{�%~�re];��t��v���l9�l�d�ʲ�$�mY(m��V$��mH�[�6�&c� �,��e�"�\�CI�2Ɇ�ۆ\�/�6@�h�F���}q�����* M1���9�;�m�����o�߶�m�����`K�c�|�$8��6��m��xr��&�X�7'��L>�]Jұ�o�N&&%|����Mbb��߰��-���c��;v�� n�N���=�����D7��c�������o�I�.�Db�7� �I �)7q�$'$��'����фN���[z��cY�jK������TR�gNAs�e`VU����O婰�'��w?$T��&�)� ��MO,��ۄ�o�O>�Pp�ۄ��ԄߦOHGt�&�~����N"��_���F~=ﱄc�S�����>C��b�����۔�c�Q�K/��M���%����)��h�:���R~:�/�R-�/*�{y�n�.�ح��c����ؿ-8w����cw~8{�n�����ԱK��M��[�x./-�,+;�033!/35!�7G��&�&����|�p�(91�X*�w�>!�������䤤c�&���L��X�ɤc�M9q,;%�XzZⱌԔc���&%1�8��oО����K�Pi��5�^���� �����r�d�Ze?c��e��|��n�'����{Ep�(�sNÝӥ�5�Kc�\��(|2�� �[=�o�XZ{i5�}Y\++'�63���0�޿�7�e����� ei� �� �u�滋g���c����ߎq�G�W�3 N����R�i~�� ��߳3ƹ�����C��(������o���>����s��.�,#/�(-;�쌄��9HgK�Zy�(̈́k��p��j��F^)�< ��΀{������ˇYip>� .dg����P�p>+�� ��p�d$&&$�����`��WܡÏ)��@G�eh:] s�Q޲+ �H��K>�r[;%YÞi�nn���Eg���K�T!�Z�(���]ӄvď�-�65/e�vu�[7v[��BN/���W��O��_�[����]]-�����:��P������ �����P�Ơ�߿���#��R�� ����ߊr�;����A�߾��8;&�r���P/ �'���?�f��_��1 Jg�c���s[�m]��B[E���3;�����_EF�}��]c8�X�����c�����7�n@��Vx�w�U��R^u'�A���"�r�Hz) �kޥF�Z]w:�����M��̫p'�<5��'�g���UķW�+`L�.��n�����Rw<. Most silvia motta tumore related news are at: – Blogger Musica: Buongiorno Buonasera è il nuovo singolo di Vittorio Merlo 11 May 2013 | 02:19 pm. Kyoko Hida, Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita‐ku, Sapporo 060‐0815, Japan. Authors declare no conflicts of interest for this article. Artificial Cells, Nanomedicine, and Biotechnology. Several molecular pathways orchestrate the complex biological cell events during a metastatic cascade. Ce la stanno mettendo tutta per recuperare il tempo perduto, cercando di ridurre i rischi per la salute che deriveranno dal blocco delle attività sanitarie di marzo-maggio scorsi: tutte le visite che non state fatte e le operazioni chirurgiche rinviate a causa dell’emergenza Covid potrebbero tradursi, per una parte dei pazienti, in malattie diagnosticate e curate più tardi del dovuto.Una volta sceso il livello di emergenza, è stata (ed è, ancora, confermano i medici) la paura del Covid a tenere lontani i pazienti dai reparti ospealieri. CXCR7 on tumor vasculature is also involved in tumor progression and metastasis. Sources of TAM are tissue‐resident macrophage, bone marrow, or spleen. Single-Cell Multiomics: Dissecting Cancer. Hipotalamus (grč. [14], PU.1 works by directly binding to the promoter of Il-9 gene and attract chromatin-modifying enzymes which reinforce Il9-gene transcription. This is the reason why only few tumor cells reach the metastatic organs, although millions of these cells are shed from a tumor into circulation every day.55 However, the viable circulating EC have been reported to be observed in the blood of cancer patients.56, 57 These results led to the conclusion that activated EC expressing high levels of adhesion molecules can bind to tumor cells, protect them from anoikis in circulation, and facilitate their movement to distant organs.54, Our group has reported the role of TEC in the initial steps of tumor metastasis.39 We have previously demonstrated the heterogeneity of TEC using two different types of TEC: HM‐TEC from highly metastatic and LM‐TEC from low metastatic tumors.58 HM‐TEC exhibited more proangiogenic phenotypes with the upregulation of angiogenesis‐related genes and more genetic instability with stem‐like phenotype and drug resistance, indicating that TEC acquire specific characteristics in response to their surrounding environment. [34] Increased levels of IL-9, mainly produced by TH9 have been detected in patients in remission phase of the disease. Join ResearchGate to find the people and research you need to help your work. While pathology and the clinical work up have for a long time pointed out the steady rate of adrenal metast... Preceded by an international overview on the surgical approach to the peripheral higher stage NSCLC, the cumulative clinical experience from ten Italian University Departments and Teaching Hospitals, is analyzed in the light of the corresponding international contributions. Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis. Activated fibroblasts in cancer are termed CAF, tumor‐associated fibroblasts, or activated myofibroblasts. [38] Also remission and faster HCV clearance was associated with lower TH9 cytokines' leves. However, tumor metastasis is still largely incurable and has become the primary cause of cancer‐related death.1 Hence, understanding the mechanism of metastasis is important to control metastatic diseases. Development of TH9 cells requires a balanced cytokines signaling for its establishment. GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial–mesenchymal transition. TAM are also known to be important components of tumor stroma. Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses. 1 0 obj Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review. Working off-campus? We here summarize the current reports pertaining to tumor stromal cells in the tumor microenvironment. >> © 2008-2020 ResearchGate GmbH. Excessive VEGF in tumors causes vessel hyperpermeability and increases IFP, which results in chaotic vessel structure. Diagnostic E valuation of P ulmonary E mbolism D uring the COVID-19 P andemic (May 2020) Lionel S. Zuckier, Renée M. Moadel, Linda B. Haramati, and Leonard Freeman Journal of Nuclear … MiR‐873 inhibition enhances gefitinib resistance in non‐small cell lung cancer cells by targeting glioma‐associated oncogene homolog 1. /Width 138 Tumor stromal cells at primary sites are hijacked to support tumor development. Tumor size was a known prognostic factor for many cancers, including NSCLC. Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications. Vi ricordate la canzone di Vittorio Merlo, La Chiesa ti uccide coll'onda? [29] They have been shown to inhibit melanoma cell growth,[30][31] increase anti-tumor lymphocytes, and drastically lower tumor mass and disease severity. In turn, Jagged1 on EC reciprocally induces Notch2–Hey1 in lymphoma cells.42 Cao et al. Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells. N Controlled Synthesis of a Vacancy‐Defect Single‐Atom Catalyst for Boosting CO2 Electroreduction. We also thank Enago for the English language review. Cifre e numeri non hanno segreti per lei e la lettura di esiti e ascolti è sempre puntuale e approfondita. The complete resection for NSCLC is analyzed through the study of a series of retrospective surgical reports upon the incomplete resection, due to a microscopic residual tumor at the resection margin. In subgroup analysis, patients with N0 presented significantly different prognosis when the ratio was divided by the median. Stage Group have become 7 out of Stage 0 (Tis). TEC, tumor endothelial cell. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in The clinical and pathological data of a single case of carcinosarcoma of the lung observed in the period from 1978 to 1998 were reviewed. TREVISO. [29], Th9 cells have also shown both pro- and anti-tumorigenic activity, depending on the type of cancer. Biglycan knockdown in HM‐TEC decreased the number of circulating tumor cells and lung metastases in vivo. -Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2) Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread. Tumor blood vessels supply nutrients and oxygen and also provide the route for metastasis. Glycosylation reactions mediated by hypervalent iodine: application to the synthesis of nucleosides and carbohydrates. In cell biology, TH9 cells (T helper type 9 cells, CD4+IL-9+IL-13−IFNγ − ) are a sub-population of CD4+T cells that produce interleukin-9 (IL-9). Effect of P2X7 receptor on tumorigenesis and its pharmacological properties. Forecasting Residential Water Consumption in California: Rethinking Model Selection. Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues. The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma. 4). The landscape of long non-coding RNAs in tumor stroma. Nanoparticle Interactions with the Tumor Microenvironment. Macrophages are classified as classically activated M1 and alternatively activated M2 macrophages.16 M1 macrophages produce proinflammatory cytokines and have antitumorigenic functions, whereas M2 macrophages promote anti‐inflammatory responses and have protumorigenic functions.17 However, it is unclear how macrophages switch from tumor‐suppressing to tumor‐promoting macrophages. . Fifty-two selected patients were classified according to the primary site and stage of disease and critically evaluated according to the results of surgical treatment. STAT5 directly bind to Il-9 gene promoter, although it has not yet been determined how important this pathway is for TH9 development in vitro and in vivo.[19][20]. Furthermore, we highlight the role of TEC in promoting tumor metastasis. Because EC in primary tumors are in close contact with tumor cells during intravasation, it is relevant that these have important roles in metastasis dissemination. Journal of Clinical and Experimental Hematopathology. La corsa di Senologia a Treviso per recuperare i ritardi. ... 5,6 Although feasible in selected patients, there is insufficient evidence to support routine resection of solitary adrenal metastasis. ὑπό – hipo = ispod + θάλαμος – talamos = komora) je dio mozga koji se sastoji od brojnih malih jezgara (jedara, nukleusa) sa različitim funkcijama. Tumor stromal cells, which acquire their specific characteristics in the tumor microenvironment, accelerate tumor malignancy. TEC‐biglycan stimulates Toll‐like receptor (TLR)‐expressing tumor cells to metastasize by activation of nuclear factor‐kappa B (NF‐κB) and extracellular signal‐regulated kinase (ERK) signaling. Slit2, which is negatively regulated by the endothelial EphA2 receptor, is one of the tumor suppressive angiocrine factors.49 The authors described that EphA2 represses Slit2 expression in EC to facilitate angiocrine‐mediated tumor invasion by blocking tumor suppressive signals.49 Such juxtacrine signals between EC and adjacent tumor cells could induce protumorigenic characteristics with increased expression of tumor‐stimulating factors or reduced expression of tumor‐suppressive factors. Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer. Interaction between malignant tumor cells and their associated stromal cells in the tumor microenvironment is crucial for tumor progression. [29] On the other hand patients suffering hepatocellular carcinoma with high TH9 infiltration had shorter disease-free survival period after surgical resection.[32]. [7][8], IL-1 may induce IL-9 in some cases, and IL-33 is able to induce IL-9 in T cells generally. Number of times cited according to CrossRef: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming. [5][2], NF-κB and NFAT1, are needed for a TCR-induced interleukin-9 production by TH9 cells. TH9 have been shown to play a role in both early and progressive phase of multiple sclerosis by decreasing the effects of pro-inflammatory TH17. Stromal cells have important roles in metastasis dissemination. It is well known that tumor progression and metastasis are not dependent on a tumor cell‐autonomous mechanism, but are controlled by the tumor microenvironment, including abnormal stromal cells.6 Fibroblasts are among the major components of tumor stroma.7 As tumors are considered wounds that do not heal,8 chronic tissue repair response occurs in tumor tissues, which causes tumor fibrosis. STAT6, IRF4, GATA3 are absolutely required for TH9 cell development[13][14] and other such as PU.1, BATF, NF-κB, NFAT1, STAT5, AP-1 contribute to TH9 sub-population commitment and to IL-9 production. Journal of Experimental & Clinical Cancer Research. Interestingly, biglycan promoter in HM‐TEC had been markedly demethylated than in the other EC (Fig. [15] Once activated, phosphorylated STAT6 mediate the transcription of Gata3 and Irf4, which are both necessary for polarization of TH9 cells. Please check your email for instructions on resetting your password. New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors. Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer. Expert recommendations on the management of hypertension in patients with ovarian and cervical cancer receiving bevacizumab in the UK. Tumor stromal cells are also known to secrete several protumorigenic factors to promote tumor growth and development.3 We studied TEC and observed several specific characteristics.4, 5 Because blood vessels surrounding tumors not only deliver nutrients and oxygen but also provide access for the tumor cells to metastasize, we assumed that TEC with abnormal phenotypes actively interact with tumor cells during tumor metastasis. T H 9 have been shown to play a role in both early and progressive phase of multiple sclerosis by decreasing the effects of pro-inflammatory T H 17. Domenico Albano, Francesco Bertagna, Mattia Bertolia, Giovanni Bosio, Silvia Lucchini, Federica Motta, Maria Beatrice Panarotto, Alessia Peli, Luca Camoni, Frank M. Bengel, and Raffaele Giubbini . TH9 cells are characterized by their cell surface expression of CD4 and CCR6 and the lack of CCR4. A 3-cm cutoff point separates T1 from T2 tumors, whereas a size larger than 3 cm is not ascribed any prognostic value. What do we have to do... more? CXCR7 is highly expressed in tumor blood vessels and is involved in tumor angiogenesis and growth.22, 50, 51 CXCR7 regulates CXCL12–CXCR4‐mediated tumor cell transendothelial migration.52 In contrast, another group demonstrated deletion of endothelial CXCR7 in conditional knockout mice, which resulted in an increased number of circulating tumor cells with elevated systemic CXCL12 levels.53 The authors suggested that CXCR7 partially functions as a scavenger receptor for CXCL12, and endothelial CXCR7 controls the amounts of systemic CXCL12.53 These findings suggest that tumor cell phenotype has plasticity and is determined by cues from TEC to confer tumors with aggressive and lethal properties. White and black circles indicate unmethylated and methylated CpG dinucleotides, respectively. Regulation of tumor–stroma interactions by the unfolded protein response. The prognosis of 545 patients with non-s... BACKGROUND: In this keynote address presented at the American Cancer Society International Conference on Prevention and Early Diagnosis of Lung Cancer, Varese, Italy, in 1998, the genesis and the activities of the International Association for the Study of Lung Cancer (IASLC) are outlined. TAM are proposed to share M2 characteristics and enhance tumor angiogenesis, resulting in tumor progression.18 TAM facilitate tumor cell intravasation through a paracrine signaling loop in which TAM‐derived EGF stimulates the invasiveness of tumor cells expressing the EGF receptor. Th9 cells can differentiate either from naive T lymphocytes or by a shift from TH2 cells. [14], BATF has been also shown to bind to the Il-9 gene promoter and to activate Il-9gene transcription. When tumor cells, particularly epithelial cells, detach from ECM in primary tumors, anoikis, which is defined as apoptosis induced by inadequate or inappropriate cell–matrix interaction, causes these cells to undergo cell‐cycle arrest and leads to rapid caspase‐mediated cell death. Because SDF1 is synthesized by other stromal cells, including pericytes, fibroblasts, or EC22, 23 in the tumor microenvironment, cross‐talk between multiple stromal and tumor cells leads to tumor progression and metastasis. Neddylation: a novel modulator of the tumor microenvironment. Tumor blood vessel pattern is complex, non‐hierarchical, and disorganized.26, 27 TEC, which line tumor blood vessels, have generally been assumed to be genetically stable. [39] This might be caused by TH9 mediated promotion of TH17 phenotype and hindering of TH1 phenotype which leads to persisting viral infection. stream Superati i 3 mila morti per il Covid in Veneto, nell'ultimo giorno altri 52 decessi, Focolaio all’Oras di Motta, 22 casi. [29], TH9 cells contribute to ulcerative colitis, due to the cell’s ability to impair cellular repair. There are many cytokines impacting differentiation of TH9 cells and their production of IL-9 but IL-4 and TGF-β are indispensable for their development and polarization. CAF, cancer‐associated fibroblast; TAM, tumor‐associated macrophage. Such a novel surgical project is supported by a large basic knowledge on molecular biology of solid tumours progression as well as the already assessed clinical experience in the parallel field of surgery for lung, brain and liver metastases. Inhibiting hypoxia and chemotherapy-induced cancer cell metastasis under valid therapeutic effect by an assistance of biomimetic oxygen delivery. AF cells were subcutaneously injected into CD nu/nu mice and tumor masses were observed 20 days later. and you may need to create a new Wiley Online Library account. Survival rates offered a strong statistical support to the latest revision in 1997. In the present review, we highlight the role of tumor stromal cells, particularly endothelial cells, in the initial steps of tumor metastasis. Tumor cells, in turn, secrete CSF1 that attracts the CSF1 receptor expressing TAM.19-21 Invasion of tumor cells can be induced by other factors such as SDF1 (also known as CXCL12). In the literature the postoperative mortality rate varies between 1.8 and 11.4% [2. (1) Tumor cells invade the surrounding stroma and extracellular matrix (ECM), (2) intravasate into the bloodstream, (3) survive in the circulation with anoikis resistance, (4) disseminate in the circulation and reach distant organs, (5) extravasate and invade into the parenchyma of distant tissues, (6) adapt to the new microenvironment and proliferate to form metastatic colonization. STAT6 is activated by signaling through IL-4 receptor. UMBERTO MOTTA ... cato un tumore. MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability. Antitumoral and Immunomodulatory Effect of Journal of Cellular and Molecular Medicine, highly metastatic tumor‐derived endothelial cell, low metastatic tumor‐derived endothelial cell. Increased levels of IL-9, mainly produced by T H 9 have been detected in patients in remission phase of the disease. Similarities between tumor stroma generation and wound healing, Carcinoma‐associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF‐1/CXCL12 secretion, Tumor cell interactions with the extracellular matrix during invasion and metastasis, The stromal proteinase MMP3/stromelysin‐1 promotes mammary carcinogenesis, PAR1 is a matrix metalloprotease‐1 receptor that promotes invasion and tumorigenesis of breast cancer cells, Cancer‐associated fibroblasts are activated in incipient neoplasia to orchestrate tumor‐promoting inflammation in an NF‐kappaB‐dependent manner, Macrophage diversity enhances tumor progression and metastasis, Exploring the full spectrum of macrophage activation, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors, Macrophages promote the invasion of breast carcinoma cells via a colony‐stimulating factor‐1/epidermal growth factor paracrine loop, Direct visualization of macrophage‐assisted tumor cell intravasation in mammary tumors, CXCL12‐CXCR7 axis is important for tumor endothelial cell angiogenic property, Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche, Tumor angiogenesis: therapeutic implications, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Probing the structural and molecular diversity of tumor vasculature, Imaging of angiogenesis: from microscope to clinic, Cellular abnormalities of blood vessels as targets in cancer, Lymphoma‐specific genetic aberrations in microvascular endothelial cells in B‐cell lymphomas, Cytogenetic abnormalities of tumor‐associated endothelial cells in human malignant tumors, Tumor endothelial cells acquire drug resistance by MDR1 up‐regulation via VEGF signaling in tumor microenvironment, Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low‐dose metronomic paclitaxel, Endothelial side population cells contribute to tumor angiogenesis and antiangiogenic drug resistance, Isolated tumor endothelial cells maintain specific character during long‐term culture, Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells, Genes expressed in human tumor endothelium, Differential vitamin D 24‐hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate, Isolation and genome‐wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue, Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan, Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance, Molecular checkpoint decisions made by subverted vascular niche transform indolent tumor cells into chemoresistant cancer stem cells, Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self‐renewal of cancer stem‐like cells, Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged‐1, Endothelial cells provide a notch‐dependent pro‐tumoral niche for enhancing breast cancer survival, stemness and pro‐metastatic properties, Endothelial Jagged1 promotes solid tumor growth through both pro‐angiogenic and angiocrine functions, Endothelial Notch1 activity facilitates metastasis, Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium, CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor‐associated vasculature, CXCR7: a novel tumor endothelial marker in renal cell carcinoma, Elucidation of CXCR7‐mediated signaling events and inhibition of CXCR4‐mediated tumor cell transendothelial migration by CXCR7 ligands, Endothelial CXCR7 regulates breast cancer metastasis, Tumor‐associated endothelial cells promote tumor metastasis by chaperoning circulating tumor cells and protecting them from anoikis, Quantitation of cell shedding into efferent blood of mammary adenocarcinoma, Resting and activated endothelial cells are increased in the peripheral blood of cancer patients, Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients, Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high‐ and low‐metastatic tumors.

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